| Sab. 14 ago. 2021 H.20:45 – Roma (Stadio Olimpico) | ||
Roma | 5-0 |  Raja Casablanca |
| 17’Shomurodov 20’Mancini 48’Mkhitaryan 85’Perez 89’Borja Mayoral | ||
| Sab. 07 ago. 2021 H.22:00 – Siviglia (Estadio Benito Villamarín) | ||
Real Betis | 5-2 | Roma |
| 4’Rodri 30’Fekir 58’Alex Moreno 80’Tello 83’Robe | 27’Shomurodov 51’Mancini | |
| Mer. 04 ago. 2021 H.12:00 – Parchal (Estadio da Bela Vista) | ||
Belenenses | 1-3 | Roma |
| 15’Ndour | 20’Dzeko 56’Zaniolo 85’Borja Mayoral | |
| Sab. 31 lug. 2021 H.18:30 – Faro (Stadio Algarve) | ||
| Siviglia | 0-0 | Roma |
| Mer. 28 lug. 2021 H.21:00 – Faro (Stadio Algarve) | ||
| Porto | 1-1 | Roma |
| 89’Vitor Ferreira | 57’Mancini | |
| Dom. 25 lug. 2021 H.19:00 – Frosinone (Benito Stirpe) | ||
Debrecen | 2-5 | Roma |
| 4’Barany 53’Ugrai | 26’Borja Mayoral 31’Pellegrini 52’Zaniolo 65’Dzeko 80’Dzeko | |
| Mer. 21 lug. 2021 H.19:30 – Triestina (Nereo Rocco) | ||
| Triestina | 0-1 | Roma |
| 49’Zalewski | ||
| Dom. 18 lug. 2021 H.18:00 – Roma (Trigoria) | ||
| Roma | 2-0 | Ternana |
| 10’Perez 53′ Kumbulla | ||
| Gio. 15 lug. 2021 H.18:00 – Roma (Trigoria) | ||
| Roma | 10-0 | Montecatini |
| 9’Perez 19’Mancini 34’Borja Mayoral 35’Calafiori 40’aut. Santi 54’Borja Mayoral 61’rig. Zaniolo 80’Zalewski 86’Diawara 88’Borja Mayoral | ||
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